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A Simple and Efficient Flow Preparation of Pyocyanin a Virulence Factor of Pseudomonas aeruginosa
Author(s) -
Mortzfeld Frederik B.,
Pietruszka Jörg,
Baxendale Ian R.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900526
Subject(s) - pyocyanin , pseudomonas aeruginosa , chemistry , reagent , yield (engineering) , flow chemistry , virulence factor , virulence , combinatorial chemistry , organic chemistry , bacteria , biochemistry , quorum sensing , genetics , biology , gene , materials science , metallurgy , catalysis
The synthesis of the naturally occurring toxin pyocyanin has been realized in a short 4 step sequence. The key photochemical reaction and isolation of the final product have been facilitated by the use of flow chemistry techniques and immobilised reagents. Using these procedures gram quantities of pyocyanin were easily prepared in high yield and purity.