Palladium‐Catalyzed Carboxy‐Alkynylation of Propargylic Amines Using Carbonate Salts as Carbon Dioxide Source | Zendy

Greenwood Phillip D. G. | Zendy; Waser Jerome | Zendy

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Palladium‐Catalyzed Carboxy‐Alkynylation of Propargylic Amines Using Carbonate Salts as Carbon Dioxide Source

Author(s) -

Greenwood Phillip D. G.,

Waser Jerome

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900500

Subject(s) - chemistry , catalysis , palladium , aryl , carbonate , caesium , alkynylation , yield (engineering) , carbon dioxide , stereoselectivity , alkyl , hydrogen , organic chemistry , medicinal chemistry , inorganic chemistry , materials science , metallurgy

A palladium‐catalyzed multicomponent reaction of propargylic amines, alkynyl bromides and cesium hydrogen carbonate to access oxazolidinones is reported. In contrast to previous reports, only a slight excess of cesium hydrogen carbonate is used as a surrogate of carbon dioxide. The reaction gives access to oxazolidinones bearing alkyl‐ and aryl polysubstituted enynes in good yield and very high E stereoselectivity.

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