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Copper(I)‐Catalyzed N ‐Carboxamidation of Indoles with Isocyanates: Facile and General Method for the Synthesis of Indole‐1‐carboxamides
Author(s) -
Chen Jinyang,
Hu Li,
Wang Haiying,
Liu Lingrong,
Yuan Binfang
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900487
Subject(s) - indole test , chemistry , catalysis , combinatorial chemistry , organic chemistry
A facile and general method for the synthesis of indole‐1‐carboxamides was developed via copper(I)‐catalyzed N ‐carboxamidation of indoles with isocyanates under mild reaction conditions. This process is scalable and tolerates a wide spectrum of indoles and isocyanates to deliver corresponding products in good to excellent yields, providing a viable synthetic approach to indole‐1‐carboxamides, which can be used for the treatment of inflammatory diseases and diabetes.