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Synthesis of Aza‐Heteroaromatic Dithiocarbamates via Cross‐Coupling Reactions of Aza‐Heteroaromatic Bromides with Tetraalkylthiuram Disulfides
Author(s) -
Cheng Chuance,
Zhao Mingqin,
Lai Miao,
Zhai Ke,
Shi Bo,
Wang Shuai,
Luo Rui,
Zhang Linbao,
Wu Zhiyong
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900475
Subject(s) - chemistry , benzothiazole , pyrazine , quinoline , pyridine , combinatorial chemistry , functional group , organic chemistry , polymer
The preparation of various aza‐heteroaromatic dithiocarbamates from aza‐heteroaromatic bromides and tetraalkylthiuram disulfides is reported. The transformation provides a convenient procedure, with good yields and functional group tolerance to various important nitrogen‐containing heteroaromatic dithiocarbamates such as benzothiazole, quinoline, pyridine, and pyrazine motifs. This protocol allows the facile synthesis of some potential biologically active compounds.