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Synthesis and Functionalization of 4‐Quinolones – A Progressing Story
Author(s) -
Ghosh Prasanjit,
Das Sajal
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900452
Subject(s) - surface modification , quinolone , chemistry , combinatorial chemistry , human immunodeficiency virus (hiv) , pharmacology , nanotechnology , antibiotics , biochemistry , virology , medicine , materials science
4‐Quinolone derivatives are serving as active components in diverse families of drugs such as antibacterial, antiviral, antimalarial, anticancer, antitumor and anti‐HIV agents. They have also attracted the significant attention in synthetic chemistry due to their prolific development, pharmacokinetic properties and good tolerability. Recent years have observed an upsurge in the modification of the 4‐quinolone scaffold. This review covers (2002 to 2019) the progress of the developments in the syntheses as well as functionalization of 4‐quinolones in different positions.