Premium
Rhodium‐Catalyzed Chemo‐, Regio‐, and Enantioselective Allylation of 2‐Aminothiazoles with Terminal Allenes
Author(s) -
Zheng Jun,
Wörl Benjamin,
Breit Bernhard
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900435
Subject(s) - enantioselective synthesis , chemistry , rhodium , catalysis , substrate (aquarium) , regioselectivity , combinatorial chemistry , stereochemistry , organic chemistry , oceanography , geology
A rhodium‐catalyzed chemo‐, regio‐ and enantioselective intermolecular coupling reaction of 2‐aminobenzothiazoles with terminal allenes is reported. The new reaction displays a wide substrate scope for both reaction partners to deliver the allylation products in good yields, with excellent regio‐ and enantioselectivity. This novel methodology was further applied in an efficient synthesis of chiral isothiourea.