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Glycoconjugates via Phosphorus Ylides
Author(s) -
Ghonchepour Ehsan,
Neochoritis Constantinos G.,
Kurpiewska Katarzyna,
KalinowskaTłuścik Justyna,
Islami Mohammad R.,
Dömling Alexander
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900434
Subject(s) - synthon , chemistry , moiety , glycoconjugate , formamides , glycosyl , ylide , combinatorial chemistry , molecule , phosphorus , surface modification , stereochemistry , organic chemistry , catalysis , biochemistry
A facile, high yielding access to rare chimeric compounds combining phosphorus ylides with complex glycosyl formamides is described. We determined X‐ray structures gaining structural insight into this compounds class. In addition, data mining of similar compounds deposited within the Cambridge Structural Database was performed. These derivatives could be used either as synthetic intermediates via the ylide functionalization and glyco chemical biology synthons or improving the pharmacokinetic properties of a potential bioactive molecule, exploiting the glycosyl moiety.