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Pd II /Novel Chiral Cinchona Alkaloid Oxazoline‐Catalyzed Enantioselective Oxidative Cyclization of Aromatic Alkenyl Amides
Author(s) -
Tian Qinqin,
Liu Yulong,
Wang Xiaoyun,
Wang Xie,
He Wei
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900431
Subject(s) - enantioselective synthesis , chemistry , cinchona , oxazoline , alkaloid , organic chemistry , catalysis , cinchona alkaloids , cinchonidine
A highly enantioselective Pd II ‐catalyzed aza‐Wacker oxidation tandem cyclization of aromatic nitrogen‐containing dienes has been achieved in the presence of novel chiral cinchona alkaloid oxazoline ligands for the first time, affording chiral dihydroindole nitrogen‐containing polycyclic compounds with good yields (up to 83 %), high diastereoselectivities (> 95:5 dr ), and excellent enantioselectivities (up to 97 % ee ).