Premium
Zinc Chloride Mediated Synthesis of 3H ‐Oxazol‐2‐one and Pyrrolo‐oxazin‐1‐one from Ynamide
Author(s) -
Habert Loïc,
Sallio Romain,
Durandetti Muriel,
Gosmini Corinne,
Gillaizeau Isabelle
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900428
Subject(s) - chemistry , zinc , chloride , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
A simple zinc chloride mediated cyclization of ynamidyl N ‐carbamates or 2‐ynamidyl‐(hetero)arylcarboxylates is achieved under mild reaction conditions, leading to the synthesis of useful heterocyclic scaffolds, 3 H ‐oxazol‐2‐ones and pyrrolo‐oxazin‐1‐ones, with good yields.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom