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Zinc Chloride Mediated Synthesis of 3H ‐Oxazol‐2‐one and Pyrrolo‐oxazin‐1‐one from Ynamide
Author(s) -
Habert Loïc,
Sallio Romain,
Durandetti Muriel,
Gosmini Corinne,
Gillaizeau Isabelle
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900428
Subject(s) - chemistry , zinc , chloride , medicinal chemistry , combinatorial chemistry , stereochemistry , organic chemistry
A simple zinc chloride mediated cyclization of ynamidyl N ‐carbamates or 2‐ynamidyl‐(hetero)arylcarboxylates is achieved under mild reaction conditions, leading to the synthesis of useful heterocyclic scaffolds, 3 H ‐oxazol‐2‐ones and pyrrolo‐oxazin‐1‐ones, with good yields.