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Modular 3D Printed Compressed Air Driven Continuous‐Flow Systems for Chemical Synthesis
Author(s) -
Penny Matthew R.,
Rao Zenobia X.,
Peniche Bruno Felício,
Hilton Stephen T.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900423
Subject(s) - modular design , footprint , chemistry , residence time (fluid dynamics) , flow (mathematics) , modularity (biology) , polypropylene , airflow , volumetric flow rate , flow chemistry , process engineering , chemical engineering , nanotechnology , mechanical engineering , organic chemistry , computer science , materials science , mechanics , engineering , catalysis , paleontology , physics , genetics , geotechnical engineering , biology , operating system
In this present study, we describe the development of a low‐cost, small‐footprint and modular 3D printed continuous‐flow system that readily attaches to existing stirrer hotplates. Flow‐rates are controlled by compressed air that is typically present in all fume hoods, making it suitable for use by synthetic chemists. The length of the flow‐path and reaction residence time is regulated by control of the air‐flow and pressure and by addition of one or more 3D printed polypropylene (PP) circular disk reactors that were designed to fit a DrySyn Multi‐E base, which is found in most synthetic laboratories. The ease of use of the system, the facile control of flow‐rates and the solvent resistance of the PP reactors was demonstrated in a range of S N Ar reactions to produce substituted ether derivatives highlighting the utility and modularity of the system.