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Palladium Catalyzed Cross ‐Dehydrogenative Coupling/Annulation Reaction: A Practical and Efficient Approach to Hydroxyisoindolo[1,2‐ b ]quinazolinone
Author(s) -
Dabiri Minoo,
Lehi Noushin Farajinia,
Movahed Siyavash Kazemi,
Khavasi Hamid Reza
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900417
Subject(s) - quinazolinone , chemistry , annulation , palladium , yield (engineering) , catalysis , benzaldehyde , toluene , intramolecular force , combinatorial chemistry , medicinal chemistry , organic chemistry , coupling reaction , materials science , metallurgy
The palladium‐catalyzed cross‐dehydrogenative coupling (CDC) followed by an intramolecular cyclization between arylquinazolinones and aldehydes has been described. This viable transformation provides a variety of novel substituted hydroxyisoindolo[1,2‐ b ]quinazolinone compounds in moderate to good yields. Additionally, the reaction is performed with toluene in place of benzaldehyde by using an excess amount of tert ‐butyl hydroperoxide (TBHP) as the oxidant in good yield.