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Minisci‐Type C–H Cyanoalkylation of Heteroarenes Through N–O/C–C Bonds Cleavage
Author(s) -
Jian Yong,
Chen Ming,
Yang Chao,
Xia Wujiong
Publication year - 2020
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900406
Subject(s) - chemistry , cleavage (geology) , radical , bond cleavage , substrate (aquarium) , stereochemistry , combinatorial chemistry , medicinal chemistry , catalysis , organic chemistry , oceanography , geotechnical engineering , fracture (geology) , engineering , geology
A visible‐light‐induced C–H cyanoalkylation of heteroarenes was described, in which cycloketone oximes were readily transformed into carbon‐centered radicals with a terminal cyano‐group via N–O/C–C bonds cleavage in one phtochemical step. This reaction protocol displayed a broad substrate scope of heterocycle compounds, and it provided a promising strategy for the installation of cyanoalkyl groups onto heteroarenes.