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Regioselective Synthesis of 2‐Arylindoles via Palladium‐Catalyzed Cyclization of Phenylglyoxal and 2‐Anilinoacetophenones with Anilines
Author(s) -
BenitezMedina G. Eliad,
OrtizSoto Sofía,
Cabrera Armando,
AmézquitaValencia Manuel
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900394
Subject(s) - chemistry , phenylglyoxal , regioselectivity , tandem , aniline , catalysis , palladium , combinatorial chemistry , organic chemistry , amino acid , biochemistry , materials science , arginine , composite material
A versatile route has been developed for the synthesis of 2‐arylindoles using a Pd‐catalyzed tandem process. Under reductive conditions, different 2‐arylindoles were synthesized from phenylglyoxal and aniline. This synthetic methodology involves a tandem reaction of four steps with high regioselectivity. Alternatively, 2‐anilinoacetophenones intermediates also can be using to give access to the corresponding 2‐arylindoles.