Tf 2 NH catalyzed 1,6‐conjugate addition of 2‐hydroxy‐ p ‐quinone methides with  β ‐Functionalized Ketones: Access to 2,3,4,9‐Tetrahydro‐1 H ‐xanthenones and 4 H ‐Chromene Derivatives | Zendy

Satbhaiya Shruti | Zendy; Khonde Nilesh S. | Zendy; Rathod Jayant | Zendy; Gonnade Rajesh | Zendy; Kumar Pradeep | Zendy

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Tf 2 NH catalyzed 1,6‐conjugate addition of 2‐hydroxy‐ p ‐quinone methides with β ‐Functionalized Ketones: Access to 2,3,4,9‐Tetrahydro‐1 H ‐xanthenones and 4 H ‐Chromene Derivatives

Author(s) -

Satbhaiya Shruti,

Khonde Nilesh S.,

Rathod Jayant,

Gonnade Rajesh,

Kumar Pradeep

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900370

Subject(s) - chemistry , conjugate , catalysis , cycloaddition , yield (engineering) , substrate (aquarium) , quinone , brønsted–lowry acid–base theory , tandem , combinatorial chemistry , organic chemistry , medicinal chemistry , mathematical analysis , materials science , oceanography , mathematics , metallurgy , composite material , geology

A Brönsted acid catalyzed tandem 1,6‐conjugate sequential cycloaddition reaction using 2‐hydroxy‐ p ‐quinone methides and β ‐functionalized ketones is reported. The method allows xanthenones and chromenes to be accessed in moderate to excellent yield with broad substrate scope, which could be further functionalized to give a versatile set of products.

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