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A Green Alternative for the Conversion of Arylboronic Acids/Esters into Phenols Promoted by a Reducing Agent, Sodium Sulfite
Author(s) -
CastroGodoy Willber D.,
Schmidt Luciana C.,
Argüello Juan E.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900311
Subject(s) - chemistry , sodium sulfite , sulfite , phenols , hydroxylation , organic chemistry , green chemistry , sodium , combinatorial chemistry , catalysis , reaction mechanism , enzyme
Hydroxylation of arylboronic acids and arylboronic esters using sodium sulfite and oxygen as the source of ultimate oxidant proceeds rapidly in water under transition metal‐free conditions. This remarkable mild and environmentally benign protocol represents a green alternative to synthesize phenols using inexpensive starting materials in a simple methodology. This new application for sodium sulfite shows a wide tolerance of functional groups, and it is compatible with oxidizable functionalities.