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Front Cover: Copper‐Catalyzed Reaction of Secondary Propargylamines with Ethyl Buta‐2,3‐dienoate for the Synthesis of 1,6‐Dihydropyridines (Eur. J. Org. Chem. 10/2019)
Author(s) -
Liu Chao,
Wang Gaigai,
Wang Yuqing,
Pereshivko Olga P.,
Peshkov Vsevolod A.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900303
Subject(s) - chemistry , cycloisomerization , front cover , copper , catalysis , pyridine , bromide , combinatorial chemistry , medicinal chemistry , organic chemistry , cover (algebra) , mechanical engineering , engineering
The Front Cover shows a new method for the fast assembly of 1,6‐dihydropyridine core through a copper(I) bromide‐catalyzed reaction of A3‐coupling‐derived propargylamines with ethyl buta‐2,3‐dienoate. The overall transformation involves the addition of secondary propargylamines to ethyl buta‐2,3‐dienoate and subsequent cycloisomerization of resulting 1,5‐enynes. The dancing couple serves as a metaphorical representation of the process underlying the alliance of science and art. More information can be found in the Full Paper by O. P. Pereshivko, V. A. Peshkov et al.