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Exploration of Catalytic Activity of Trypsin for C(sp 3 )‐H Functionalization and Consequent C‐C Bond Formation
Author(s) -
Shukla Ratnakar Dutt,
Rai Byanju,
Kumar Atul
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900290
Subject(s) - surface modification , chemistry , trypsin , benzoxazole , stereochemistry , catalysis , combinatorial chemistry , enzyme , organic chemistry
Employment of trypsin for C(sp 3 )‐H functionalization to construct a new C‐C bond utilizing 2‐methylbenzothiazole/2‐methyl benzoxazole with diones has been explored. This novel and greener approach have been effectively utilized to afford bioactive 3‐substituted‐3‐Hydroxy‐2‐oxindoles. Furthermore, the presented method combines the enzyme promiscuity and C‐H functionalization which open up and expands the repertoire of chemoenzymatic C‐H functionalization.