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Palladium‐Catalyzed Carbonylative Synthesis of N ‐Heterocycles from 1‐Chloro‐2‐fluorobenzenes
Author(s) -
Yuan Yang,
Wu XiaoFeng
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900232
Subject(s) - chemistry , annulation , palladium , carbonylation , catalysis , nucleophilic substitution , nucleophile , combinatorial chemistry , medicinal chemistry , organic chemistry , carbon monoxide
A simple and efficient synthesis of pyrido‐fused quinazolinones and dibenzoxazepinones by palladium‐catalyzed annulation of commercially available substituted 1‐chloro‐2‐fluorobenzenes and 2‐aminopyridines or 2‐aminophenols has been developed. The reaction involves carbonylation/aromatic nucleophilic substitution sequential in a one‐pot manner.
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