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Front Cover: Copper‐Catalyzed Four‐Component Reaction for the Synthesis of N ‐Difluoroethyl Imides (Eur. J. Org. Chem. 8/2019)
Author(s) -
Gao Yu,
Peng ShanQing,
Liu DeYong,
Rui PeiXin,
Hu XiangGuo
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900227
Subject(s) - chemistry , front cover , diazomethane , catalysis , copper , combinatorial chemistry , molecule , component (thermodynamics) , cover (algebra) , stereochemistry , organic chemistry , mechanical engineering , physics , engineering , thermodynamics
The Front Cover shows a general and efficient method for the synthesis of N ‐difluoroethyl imides. This copper‐catalyzed four component reaction proceeds via in situ generated difluoromethyl diazomethane, which does not require a prior formation and transferring. The reaction is scalable, tolerant of a range of functional groups, and also suitable for the late‐stage functionalization of drugs and drug‐like molecules. More information can be found in the Full Paper by X.‐G. Hu et al.