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Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®
Author(s) -
Soldatova Natalia S.,
Postnikov Pavel S.,
Yusubov Mekhman S.,
Wirth Thomas
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900220
Subject(s) - chemistry , flow chemistry , continuous flow , flow (mathematics) , combinatorial chemistry , organic chemistry , catalysis , biochemical engineering , geometry , mathematics , engineering
Flow chemistry is considered to be a versatile and complementary methodology for the preparation of valuable organic compounds. We describe a straightforward approach for the synthesis of iodonium trifluoroacetates through the direct oxidation of iodoarenes in a simple flow reactor using an Oxone‐filled cartridge. Optimization has been carried out using the Nelder–Mead algorithm. The procedure allows a wide range of iodonium salts to be prepared from simple starting materials.