Consecutive Five‐Component Ugi‐4CR‐CAL B‐Catalyzed Aminolysis Sequence and Concatenation with Transition Metal Catalysis in a One‐Pot Fashion to Substituted Triamides | Zendy

Gesse Pascal | Zendy; Müller Thomas J. J. | Zendy

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Consecutive Five‐Component Ugi‐4CR‐CAL B‐Catalyzed Aminolysis Sequence and Concatenation with Transition Metal Catalysis in a One‐Pot Fashion to Substituted Triamides

Author(s) -

Gesse Pascal,

Müller Thomas J. J.

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201900198

Subject(s) - aminolysis , chemistry , catalysis , cycloaddition , alkyne , transition metal , combinatorial chemistry , concatenation (mathematics) , organic chemistry , stereochemistry , mathematics , combinatorics

The concatenation of the Ugi four‐component synthesis and the CAL B‐catalyzed aminolysis of the intermediary formed Ugi methyl ester products furnishes a novel consecutive five‐component reaction for the formation of triamides. This one‐pot process is excellently compatible with metal catalyzed processes, such as copper‐catalyzed alkyne‐azide cycloaddition and Suzuki cross‐coupling or both in a one‐pot fashion. These novel consecutive six‐component syntheses represent a practical tool for synthesizing substrate libraries of complex triamide structures in a diversity‐oriented fashion.

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