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Consecutive Five‐Component Ugi‐4CR‐CAL B‐Catalyzed Aminolysis Sequence and Concatenation with Transition Metal Catalysis in a One‐Pot Fashion to Substituted Triamides
Author(s) -
Gesse Pascal,
Müller Thomas J. J.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900198
Subject(s) - aminolysis , chemistry , catalysis , cycloaddition , alkyne , transition metal , combinatorial chemistry , concatenation (mathematics) , organic chemistry , stereochemistry , mathematics , combinatorics
The concatenation of the Ugi four‐component synthesis and the CAL B‐catalyzed aminolysis of the intermediary formed Ugi methyl ester products furnishes a novel consecutive five‐component reaction for the formation of triamides. This one‐pot process is excellently compatible with metal catalyzed processes, such as copper‐catalyzed alkyne‐azide cycloaddition and Suzuki cross‐coupling or both in a one‐pot fashion. These novel consecutive six‐component syntheses represent a practical tool for synthesizing substrate libraries of complex triamide structures in a diversity‐oriented fashion.