Premium
General Platform for the Conversion of Isoxazol‐5‐ones to 3,5‐Disubstituted Isoxazoles via Nucleophilic Substitutions and Palladium Catalyzed Cross‐Coupling Strategies
Author(s) -
Fernandes Alessandra A. G.,
da Silva Amanda F.,
Okada Celso Y.,
Suzukawa Vitor,
Cormanich Rodrigo A.,
Jurberg Igor D.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900187
Subject(s) - chemistry , palladium , nucleophile , aryl , catalysis , alkyl , nucleophilic addition , combinatorial chemistry , coupling (piping) , medicinal chemistry , organic chemistry , stereochemistry , mechanical engineering , engineering
A general platform for the conversion of isoxazol‐5‐ones to 3,5‐disubstituted isoxazoles has been developed via a two‐step strategy. The first step leads to the formation of 5‐(pseudo)halogenated isoxazoles, while in the second, a variety of heteroalkyl‐, heteroaryl‐, alkyl‐, alkenyl‐, alkynyl‐ and aryl‐chains can be installed via nucleophilic substitutions or palladium catalyzed cross‐coupling reactions.