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Non‐Aromatic 3 H ‐Pyrroles in the Reaction with Nucleophiles: Is High Reactivity a Myth?
Author(s) -
Shabalin Dmitrii A.,
Kuzmin Anton V.,
Schmidt Elena Yu.,
Trofimov Boris A.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900152
Subject(s) - chemistry , reactivity (psychology) , nucleophile , pyrrole , sulfur , organic chemistry , medicinal chemistry , nitrogen , computational chemistry , photochemistry , combinatorial chemistry , catalysis , medicine , alternative medicine , pathology
The reactivity of azadiene system of non‐aromatic 3 H ‐pyrroles toward nitrogen‐, oxygen‐, and sulfur‐nucleophiles has been evaluated both experimentally and theoretically. The obtained results demonstrate, for the first time, low reactivity of 3 H ‐pyrrole system and allow future research directions in the chemistry of this unique heterocyclic scaffold to be formulated.