Premium
Transition‐Metal‐Free Heterobiaryl Synthesis via Aryne Coupling
Author(s) -
Saied Tarak,
Demangeat Catherine,
Panossian Armen,
Leroux Frédéric R.,
Fort Yves,
Comoy Corinne
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900130
Subject(s) - aryne , reactivity (psychology) , coupling (piping) , chelation , transition metal , chemistry , combinatorial chemistry , salt (chemistry) , computational chemistry , organic chemistry , materials science , catalysis , metallurgy , medicine , alternative medicine , pathology
We disclose, for the first time, an efficient route for the construction of various heterobiaryl backbones in fair to excellent yields using the Aryne coupling methodology. This study outlined the remarkable effect of external chelating ligands and salt additives on the heterocyclic partner reactivity in the aryne coupling reaction.