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Chemodiscrimination of Olefin Bonds Through Cross‐Metathesis Reactions – Synthesis of Functionalized β‐Lactam and β‐Amino Acid Derivatives
Author(s) -
n Melinda,
Benke Zsanett,
Fustero Santos,
Fülöp Ferenc,
Kiss Loránd
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900101
Subject(s) - chemistry , metathesis , olefin metathesis , lactam , bicyclic molecule , catalysis , ring (chemistry) , salt metathesis reaction , substrate (aquarium) , combinatorial chemistry , olefin fiber , amino esters , stereochemistry , amino acid , double bond , organic chemistry , polymerization , biochemistry , oceanography , geology , polymer
Chemodifferentiation of C=C bonds of various diolefinated β‐lactams or β‐amino esters has been investigated through cross‐metathesis reactions. The transformations involved substrate‐dependent cross‐metathesis of dialkenylated azetidinones, derived from the ring opening of constrained unsaturated bicyclic β‐lactam isomers. Cross‐metathesis reactions have been carried out under various conditions and catalysts in view of chemodiscrimination affording functionalized β‐lactams or β‐amino acid derivatives.