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Organocatalytic Asymmetric Michael–Acyl Transfer Reaction of α‐Nitroketones with 2‐Hydroxybenzylidene Ketones
Author(s) -
Maity Rajendra,
Sahoo Subas Chandra,
Pan Subas Chandra
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900069
Subject(s) - chemistry , organocatalysis , michael reaction , benzoic acid , catalysis , transfer hydrogenation , ketone , cascade reaction , organic chemistry , reaction conditions , combinatorial chemistry , enantioselective synthesis , stereochemistry , ruthenium
An organocatalytic asymmetric cascade Michael–acyl transfer reaction between 2‐hydroxybenzylidene ketones and α ‐nitroketones is developed. The 9‐amino(9‐deoxy)‐ epi ‐hydroquinine catalyst in combination with benzoic acid was found to be the most effective for this reaction and the desired products were isolated in moderate to good yields and excellent enantioselectivities.