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Amination of 2‐Pyridinesulfonic and 8‐Quinolinesulfonic Acids with Magnesium Amides
Author(s) -
Balkenhohl Moritz,
Valsamidou Vasiliki,
Knochel Paul
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900057
Subject(s) - chemistry , amination , aminopyridines , magnesium , organic chemistry , pyridine , 2 aminopyridine , catalysis
The amination of 2‐pyridine‐ and 8‐quinolinesulfonic acids using magnesium amides of the type R 2 NMgCl · LiCl is reported. Thus, several cyclic and acyclic amines were converted into the corresponding amides using i PrMgCl · LiCl, which reacted readily with sulfonic acids to produce aminopyridines and aminoquinolines. Various amines which are attractive in drug chemistry were suitable for this transformation.