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Ruthenium(II)‐Catalyzed C–H Alkenylation of Quinones: Diversity‐Oriented Strategy for Trypanocidal Compounds
Author(s) -
Dias Gleiston G.,
Nascimento Tamires A. do,
de Almeida Andresa K. A.,
Bombaça Ana Cristina S.,
MennaBarreto Rubem F. S.,
Jacob Claus,
Warratz Svenja,
da Silva Júnior Eufrânio N.,
Ackermann Lutz
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201900004
Subject(s) - ruthenium , chemistry , trypanosoma cruzi , catalysis , chagas disease , combinatorial chemistry , ring (chemistry) , stereochemistry , organic chemistry , parasite hosting , virology , biology , world wide web , computer science
Ruthenium(II)‐catalysis enabled C–H alkenylations of unactivated naphthoquinones for the preparation of A‐ring‐modified naphthoquinoidal compounds with activity against Trypanosoma cruzi , the parasite causing Chagas disease. The present study encompasses C–H alkenylation by weak O ‐coordination by means of ruthenium(II) carboxylates. This method provided an efficient and versatile tool towards a diversity‐oriented strategy for the preparation of compounds with a relevant biological profile.