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Ammonium Persulfate Promotes Radical Cyclization of 1,3‐Dicarbonyl‐Ugi 4‐CR Adducts: Synthesis of Polysubstituted γ‐Lactams in Aqueous Media
Author(s) -
BorjaMiranda Andrés,
SánchezChávez Anahí Carolina,
PolindaraGarcía Luis A.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801871
Subject(s) - ammonium persulfate , chemistry , atom economy , persulfate , adduct , aqueous solution , aqueous medium , ammonium acetate , combinatorial chemistry , ugi reaction , ammonium , radical cyclization , organic chemistry , medicinal chemistry , catalysis , isocyanide , polymer , high performance liquid chromatography , polymerization
The development of a practical and efficient combinatorial synthesis of γ‐lactams from 1,3‐dicarbonyl‐Ugi 4‐CR adducts by means of a radical cyclization–oxyamination process promoted by ammonium persulfate and TEMPO is described. The two‐step methodology allows the construction of a series of polysubstituted γ‐lactams with a high atom economy in good to excellent yields under mild reaction conditions.