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Front Cover: On the Stability of Disubstituted Cyclobutenes – A Computational Study (Eur. J. Org. Chem. 2‐3/2019)
Author(s) -
Maryasin Boris,
Maulide Nuno
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801854
Subject(s) - chemistry , substituent , front cover , ring (chemistry) , intramolecular force , cover (algebra) , quantum chemical , computational chemistry , quantum chemistry , matrix (chemical analysis) , stereochemistry , reaction mechanism , molecule , organic chemistry , catalysis , mechanical engineering , engineering , chromatography
The Front Cover shows free energy profiles of the ring‐opening reactions for two different cyclobutenecarboxylic acids. The kinetic barrier for this process critically depends on the substituent at the four‐membered ring. Quantum chemical calculations reveal and elucidate the role of intramolecular interactions within the respective transition state. Combining computation with organic synthesis has a revealing effect akin to that of the red pill of reality in the Matrix. Cover design by Giovanni Di Mauro and Boris Maryasin. More information can be found in the Full Paper by B. Maryasin and N. Maulide .