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Hypervalent Iodine‐Mediated Cyclization of Homotryptamine Derivatives
Author(s) -
Jiang Xinpeng,
Zhu Weijie,
Yang Liechao,
Zheng Zicong,
Yu Chuanming
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801842
Subject(s) - hypervalent molecule , chemistry , iodine , combinatorial chemistry , scope (computer science) , transformation (genetics) , substrate (aquarium) , stereochemistry , organic chemistry , programming language , biochemistry , oceanography , computer science , gene , geology
A facile and efficient cyclization of homotryptamines and their derivatives has been established for the construction of 4a‐chlorotetrahydropyrido[2,3‐b]indoles and 3,3‐spirocyclic 3H‐indoles using hypervalent iodine (1‐chloro‐1,2‐benziodoxol‐3‐one) under mild conditions. The broad substrate scope and successful gram‐scale experiment grant this metal‐free transformation great potential for further application.