2‐Azidoethane‐1‐sulfonylfluoride (ASF): A Versatile  Bis ‐clickable Reagent for SuFEx and CuAAC Click Reactions | Zendy

Zhang Xu | Zendy; Moku Balakrishna | Zendy; Leng Jing | Zendy; Rakesh K. P. | Zendy; Qin HuaLi | Zendy

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2‐Azidoethane‐1‐sulfonylfluoride (ASF): A Versatile Bis ‐clickable Reagent for SuFEx and CuAAC Click Reactions

Author(s) -

Zhang Xu,

Moku Balakrishna,

Leng Jing,

Rakesh K. P.,

Qin HuaLi

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201801825

Subject(s) - reagent , click chemistry , chemistry , dendrimer , combinatorial chemistry , yield (engineering) , fluoride , organic chemistry , materials science , inorganic chemistry , metallurgy

A new reagent, 2‐azidoethane‐1‐sulfonylfluoride (ASF), was synthesized from 2‐chloroethane‐1‐sulfonyl fluoride in 50g‐scale with 87 % yield. This novel reagent possesses two selectively clickable functionalities to be used for both CuAAC and SuFEx click reactions. The application of this reagent ASF to the construction of a class of novel 1,2,3‐triazole derived S(VI)‐F analogs was achieved in a quick, efficient and atom‐economical manner. Orthogonally clickable construction of a new class of dendrimers was also accomplished.

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