Base‐Promoted Oxidative C(sp 3 )–S Bond Cross‐Coupling of Inactive Fluorenes and Thiols for the Synthesis of 9‐Monothiolated Fluorenes | Zendy

Liu Yafeng | Zendy; Yuan Xinglong | Zendy; Su Kexin | Zendy; Tian Yuan | Zendy; Chen Baohua | Zendy

Premium

Base‐Promoted Oxidative C(sp 3 )–S Bond Cross‐Coupling of Inactive Fluorenes and Thiols for the Synthesis of 9‐Monothiolated Fluorenes

Author(s) -

Liu Yafeng,

Yuan Xinglong,

Su Kexin,

Tian Yuan,

Chen Baohua

Publication year - 2019

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201801806

Subject(s) - chemistry , fluorene , fluorine , oxidative coupling of methane , medicinal chemistry , catalysis , photochemistry , stereochemistry , organic chemistry , polymer

The highly efficient and selective C(sp 3 )–S bond cross‐coupling method for the synthesis of 9‐thiolated fluorenes through a direct thiolation at 9‐C(sp 3 )–H of fluorenes with thiols is described. This reaction occurs at ambient conditions and shows good tolerance of functional groups including arylthiols and alkylthiols. A wide range of products is obtained in moderate to good yields. Besides, the reaction of benzothiophenol and fluorine generates unexpected 9‐benzylidene‐9 H ‐fluorene by eliminating hydrogen sulfide.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research