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The Synthesis of (±)‐Oxyisocyclointegrin
Author(s) -
Smith Robert J.,
Bower Rebekah L.,
Ferguson Scott A.,
Rosengren Rhonda J.,
Cook Greg M.,
Hawkins Bill C.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801751
Subject(s) - chemistry , diketone , total synthesis , stereochemistry , core (optical fiber) , combinatorial chemistry , composite material , materials science
The total synthesis of oxyisocyclointegrin is described. The key steps in the synthesis included a Tsuji–Trost allyl migration to exclusively afford the corresponding monoallylated 1,3‐diketone and a photochemical initiated oxidative cyclization to forge the oxepine core.