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A HELIXOL‐Derived Bisphosphinite Ligand: Synthesis and Application in Gold‐Catalyzed Enynes Cycloisomerization
Author(s) -
Medena Caleb,
Calogero Francesco,
Lemoine Quentin,
Aubert Corinne,
Derat Etienne,
Fensterbank Louis,
Gontard Geoffrey,
Khaled Omar,
Vanthuyne Nicolas,
Moussa Jamal,
Ollivier Cyril,
Petit Marc,
Barbazanges Marion
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801722
Subject(s) - cycloisomerization , catalysis , ligand (biochemistry) , combinatorial chemistry , helicene , chemistry , cobalt , organic chemistry , molecule , receptor , biochemistry
The synthesis, optical resolution through derivatization, characterization, and utilization of a new helical bis(phosphinite gold) complex derived from HELIXOL are described. By using an efficient cobalt catalyst, neither irradiation nor high catalytic loading was required to access the helicene of interest. The latter was phosphorylated to afford a new chiral ligand that was studied. Especially, treatment with AuCl(SMe 2 ) gives a dinuclear gold complex that was used in cycloisomerization reactions.