Synthesis of Dihydroisobenzofuran Carboxaldehyde Derivatives by a Silver‐Catalyzed Sequential Protodesilylation/Cyclization/Oxidation Reaction

A new synthetic methodology has been developed for the synthesis of dihydroisobenzofuran carboxaldehyde derivatives. The reaction proceeds by a silver‐catalyzed protodesilylation/5‐exo‐dig cyclization/oxidation reaction to provide a broad scope of products with yields ranging from 55–91 %. Control experiments show that protodesilylation precedes the 5‐exo‐dig cyclization step in the catalytic cycle. The synthetic utility of these highly functionalized products was showcased through a number of chemoselective chemical transformations.