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Metal‐Free Access to ( E/Z )‐α‐Fluorovinyl Phosphorus Compounds from gem ‐Difluorostyrenes
Author(s) -
Peng Yingyuan,
Zhang Xiaofei,
Qi Xueyu,
He Qian,
Zhang Bin,
Hao Jian,
Yang Chunhao
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801602
Subject(s) - chemistry , phosphine , phosphine oxide , phosphorus , organic chemistry , oxide , diphenylphosphine , phosphate , metal , column chromatography , catalysis
A facile and efficient method for the synthesis of ( E/Z )‐α‐fluorovinyl phosphorus compounds from gem ‐difluorostyrenes with diphenylphosphine oxide/dialkyl phosphate and DBU at room temperature was developed. A series of 1‐fluorovinyl phosphine oxides/phosphonates were obtained with moderate to excellent yields in these reactions. Additionally, most isomers ( E/Z type) of the target compounds could be easily separated and purified by column chromatography.
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