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Front Cover: Total Synthesis of Estradiol Methyl Ether and Its Five‐Pot Synthesis with an Organocatalyst (Eur. J. Org. Chem. 41/2018)
Author(s) -
Koshino Seitaro,
Kwon Eunsang,
Hayashi Yujiro
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801580
Subject(s) - chemistry , front cover , one pot synthesis , domino , yield (engineering) , organic chemistry , total synthesis , ether , catalysis , cascade reaction , cover (algebra) , combinatorial chemistry , mechanical engineering , engineering , materials science , metallurgy
The Front Cover shows a new efficient, pot‐economical synthesis of estradiol methyl ether using an organocatalyst‐mediated asymmetric domino reaction as a key step. Multistep reactions were conducted in one reaction vessel according to our concept of the pot economy. The reaction vessel is illustrated as a cooking pot, while the key organocatalyst as sparkling spices. As a result, the synthesis was achieved in 15% yield with only five steps. More information can be found in the Full Paper by Y. Hayashi et al.