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Direct Synthesis of Indanes via Iron‐Catalyzed Dehydrative Coupling/Friedel–Crafts Cyclization of Two Different Alcohols
Author(s) -
Sai Masahiro
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801573
Subject(s) - chemistry , friedel–crafts reaction , catalysis , organic chemistry , cascade , combinatorial chemistry , chromatography
We report herein a novel iron‐catalyzed cascade dehydrative coupling/Friedel–Crafts cyclization of two different alcohols, providing a variety of indanes, which are ubiquitous substructures found in natural products, pharmaceuticals, and functional materials. Importantly, the developed approach is highly atom‐economic and environmentally benign, as it employs readily available alcohols as substrates and generates water as the only byproduct.