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Arylzinc Halides by Silver Catalyzed Zinc Insertion into Aryl Iodides
Author(s) -
Casotti Gianluca,
Iuliano Anna,
Carpita Adriano
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801543
Subject(s) - negishi coupling , chemistry , metalation , aryl , zinc , catalysis , halide , solvent , combinatorial chemistry , metal , organic chemistry , polymer chemistry , alkyl
A catalytic amount of silver acetate efficiently promotes direct insertion of zinc metal into aryl iodides, having different structure, in ethereal solvent. Electron‐rich substrates also rapidly undergo oxidative metalation. The arylzinc iodides formed give Negishi coupling products under mild reaction conditions to obtain biaryls in high yields. Sensitive functional groups like aldehydes and primary amides are well‐tolerated.