Premium
Rhodium(III)‐Catalyzed C–H Alkylation/Nucleophilic Addition Domino Reaction
Author(s) -
Tang Mengyao,
Li Yunpeng,
Han Shengnan,
Liu Lei,
Ackermann Lutz,
Li Jie
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801535
Subject(s) - chemistry , rhodium , nucleophile , catalysis , alkylation , atom economy , aryl , cascade reaction , nucleophilic addition , functional group , selectivity , medicinal chemistry , substrate (aquarium) , combinatorial chemistry , organic chemistry , alkyl , oceanography , geology , polymer
A C–H alkylation/nucleophilic addition manifold with synthetically useful aryl oximes and pyrazoles was realized by rhodium(III) catalysis under remarkably mild reaction conditions. Valuable β‐acyl substituted arylbutanoates were obtained in moderate to good yields. This strategy is characterized by excellent atom‐ and step‐economy, high chemo‐ and site‐selectivity, a broad substrate scope, and a wide functional group tolerance.