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Ruthenium‐Catalyzed C–H Selenylations of Benzamides
Author(s) -
Ma Wenbo,
Weng Zhengyun,
Fang Xinyue,
Gu Linghui,
Song Yupin,
Ackermann Lutz
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801532
Subject(s) - chemistry , ruthenium , benzamide , amide , catalysis , electrophile , aldehyde , electrophilic substitution , combinatorial chemistry , functional group , organic chemistry , medicinal chemistry , polymer
A convenient and effective protocol for the ruthenium‐catalyzed C–H selenylations of benzamide was achieved under mild reaction conditions. The robust ruthenium catalyst tolerated a wide range of functional groups and set the stage for the preparation for diversely decorated benzamides. The amide directing group could be transferred to carboxylic acid, aldehyde and tetrazoles. Preliminary mechanistic study indicated a base‐assisted electrophilic‐type substitution C–H activation event.