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Metal‐Free Visible‐Light Photocatalytic Tandem Radical Addition–Cyclization Strategy for the Synthesis of Sulfonyl‐Containing Isoquinolinediones
Author(s) -
Zuo KaiLi,
He YanHong,
Guan Zhi
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801519
Subject(s) - sulfonyl , chemistry , tandem , radical , eosin y , cascade reaction , catalysis , photoredox catalysis , visible spectrum , combinatorial chemistry , photochemistry , radical cyclization , photocatalysis , functional group , free radical reaction , organic chemistry , alkyl , materials science , physics , optoelectronics , polymer , composite material
A mild radical cascade reaction for the synthesis of sulfonyl‐containing isoquinolinediones has been developed, in which sulfonyl radicals can be accessed from simple sodium sulfinates under visible light and eosin Y catalysis. This tandem approach features a broad range of substrates and functional group tolerance. With this strategy, trifluoromethylated isoquinolinedione was also obtained.