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Nickel‐Catalyzed Directed Hydroarylation of Alkynes with Boronic Acids
Author(s) -
Hanna Luke E.,
Konev Mikhail O.,
Jarvo Elizabeth R.
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801494
Subject(s) - chemistry , stereoselectivity , catalysis , olefin fiber , nickel , reaction conditions , combinatorial chemistry , base (topology) , organic chemistry , mathematical analysis , mathematics
A regio‐ and stereoselective nickel‐catalyzed hydroarylation of alkynes using propargylic carbamates as directing groups has been developed. The reaction proceeds under mild reaction conditions using arylboronic acids in the absence of base. A range of heterocycles and functional groups are tolerated under the reaction conditions, providing high yields of trisubstituted alkenes with control of olefin geometry.