Premium
An Efficient Synthesis of Benzyl Dithiocarbamates by Base‐Promoted Cross‐Coupling Reactions of Benzyl Chlorides with Tetraalkylthiuram Disulfides at Room Temperature
Author(s) -
Wu Zhiyong,
Lai Miao,
Zhang Siyuan,
Zhong Xianyun,
Song Hao,
Zhao Mingqin
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801449
Subject(s) - chemistry , dithiocarbamate , base (topology) , coupling reaction , benzyl chloride , combinatorial chemistry , organic chemistry , catalysis , mathematical analysis , mathematics
A straightforward, mild and efficient protocol for the synthesis of benzyl dithiocarbamates from benzyl chlorides and tetraalkylthiuram disulfides is presented. This protocol is compatible with a wide variety of electron‐donating and ‐withdrawing substituents and enables construction of various dithiocarbamate derivatives from readily available starting materials.