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Cover Feature: 2‐Acetamido‐2‐deoxy‐ l ‐iminosugar C ‐Alkyl and C ‐Aryl Glycosides: Synthesis and Glycosidase Inhibition (Eur. J. Org. Chem. 40/2018)
Author(s) -
Fontelle Nathalie,
Yamamoto Arisa,
Arda Ana,
JiménezBarbero Jesús,
Kato Atsushi,
Désiré Jérôme,
Blériot Yves
Publication year - 2018
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801420
Subject(s) - iminosugar , chemistry , aryl , alkyl , stereochemistry , wittig reaction , organic chemistry , enzyme
The Cover Feature shows the synthesis of unprecedented 2‐acetamido C ‐alkyl and C ‐aryl iminosugars. This synthesis was achieved through a Staudinger/aza‐Wittig/ Grignard/ring contraction sequence. An audacious parallel is made between Louis Blériot's achievement, being the first to fly an aircraft across the English Channel in 1909 and this work, the first “trip” to 2‐acetamido C ‐alkyl and C ‐aryl iminosugars, achieved by his relative and collaborators. The cover art was created by S. Riffaut. More information can be found in the Full Paper by Y. Blériot, A. Kato, J. Désiré et al.