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Synthesis of Nitriles from Aldehydes with Elongation of the Molecule with Two Carbon Atoms
Author(s) -
Afanasyev Oleg I.,
Zarochintsev Alexander,
Petrushina Tatiana,
Cherkasova Anastasia,
Denisov Gleb,
Cherkashchenko Ilia,
Chusova Olga,
Jinho Oh,
ManSeog Chun,
Usanov Dmitry L.,
Semenov Sergei E.,
Chusov Denis
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801412
Subject(s) - chemistry , reagent , molecule , catalysis , aldehyde , elongation , combinatorial chemistry , carbon fibers , iron pentacarbonyl , organic chemistry , materials science , composite number , metallurgy , composite material , ultimate tensile strength
A new protocol for the synthesis of nitriles from carbonyl compounds with elongation of the molecule with two carbon atoms was developed. It involves a reaction of ethyl cyanoacetate with different aldehydes in the presence of iron pentacarbonyl as a reducing agent. This protocol is very simple and requires only commonly available reagents, with no catalyst or complicated ligands being employed.