Regioselective Hydrodehalogenation of Aromatic α‐ and β‐Halo carbonyl Compounds by CuI in Isopropanol

An operationally efficient and regioselective hydrodehalogenation methodology of aromatic α‐ and β‐halo carbonyl compounds has been developed using CuI in isopropanol at 90 °C under basic condition. The catalytic system effectively dehalogenates chloride, bromide, and iodide groups and afforded high yield (up to 97 %) as carbonyl compounds. The methodology is environmentally friendly and demonstrates excellent tolerance to a broad range of electronically rich and poor substituents.