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Regioselective Hydrodehalogenation of Aromatic α‐ and β‐Halo carbonyl Compounds by CuI in Isopropanol
Author(s) -
Parveen Iram,
Khan Danish,
Ahmed Naseem
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801385
Subject(s) - chemistry , regioselectivity , iodide , bromide , yield (engineering) , organic chemistry , catalysis , chloride , materials science , metallurgy
An operationally efficient and regioselective hydrodehalogenation methodology of aromatic α‐ and β‐halo carbonyl compounds has been developed using CuI in isopropanol at 90 °C under basic condition. The catalytic system effectively dehalogenates chloride, bromide, and iodide groups and afforded high yield (up to 97 %) as carbonyl compounds. The methodology is environmentally friendly and demonstrates excellent tolerance to a broad range of electronically rich and poor substituents.