Preparation and Reactions of CF 3 ‐Containing Phthalides | Zendy

Mitobe Kana | Zendy; Terashima Kyu | Zendy; KawasakiTakasuka Tomoko | Zendy; Agou Tomohiro | Zendy; Kubota Toshio | Zendy; Yamazaki Takashi | Zendy

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Preparation and Reactions of CF 3 ‐Containing Phthalides

Author(s) -

Mitobe Kana,

Terashima Kyu,

KawasakiTakasuka Tomoko,

Agou Tomohiro,

Kubota Toshio,

Yamazaki Takashi

Publication year - 2018

Publication title -

european journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.825

H-Index - 155

eISSN - 1099-0690

pISSN - 1434-193X

DOI - 10.1002/ejoc.201801384

Subject(s) - chemistry , reagent , moiety , alkoxy group , trifluoromethyl , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , alkyl

We have demonstrated that reactions of aromatic 1,2‐diesters and the Ruppert–Prakash reagent (TMSCF 3 ) afforded hitherto unknown phthalides 1 with both trifluoromethyl (CF 3 ) and alkoxy groups at the 3 position, and their unique transformation was also investigated in detail to attain construction of a variety of very rare types of compounds, such as 1,3‐dihydroisobenzofurans 8 as well as indanones 9 with a CF 3 moiety, whose behavior was completely different from the structurally similar compound 2a .

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