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Versatile Synthesis of 4‐Aryl Chroman and 1‐Aryl Tetralins Through Metal‐Free Reductive Arylations
Author(s) -
Panda Gautam,
Kumar M Srinivas Lavanya
Publication year - 2019
Publication title -
european journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.825
H-Index - 155
eISSN - 1099-0690
pISSN - 1434-193X
DOI - 10.1002/ejoc.201801375
Subject(s) - chemistry , aryl , combinatorial chemistry , organic chemistry , alkyl
A metal free approach was developed for accessing 4‐aryl chromans and 1‐aryl tetralins from their commercially available building blocks. This operationally simple protocol was well tolerated with the presence of labile functional groups, providing biologically relevant chemical libraries, which can be used for late stage modification. Dearylated analogues of the drugs Ormeloxifene and Lasofoxifene were synthesized using this approach.